A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms

Abstract excerpt

<h4>ABSTRACT</h4> Myeloproliferative neoplasms (MPNs) are chronic blood diseases with significant morbidity and mortality. While sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a significant proportion of patients progressing to rapidly fatal secondary acute myeloid leukemia (sAML). Therapeutic discovery has been hampered by the inability of g...

Topics

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• Calreticulin
• Clonal Evolution
• Disease Models, Animal
• Leukemia, Myeloid, Acute
• Mice
• Mutation
• Myeloproliferative Disorders
• Neoplasms

Identifiers and source

Literature Corpus work

a18cfed7-72a1-5e5c-a778-5ff98c23617b

DOI

10.1101/2020.11.12.378810