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Article

Overview of Transgenic Mouse Models of Myeloproliferative Neoplasms (MPNs).

Current protocols in pharmacology - 22 Jun 2017

Dunbar Andrew, Nazir Abbas, Levine Ross

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are a class of hematologic diseases characterized by aberrant proliferation of one or more myeloid lineages and progressive bone marrow fibrosis. In 2005, seminal work by multiple groups identified the JAK2V617F mutation in a significant fraction of MPN patients. Since that time, murine models of JAK2V617F have greatly enhanced the understanding of the role of aberrant JAK-STAT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28640953
DOI: 10.1002/cpph.23
PMCID: PMC6352313

Genes

CALR
JAK2
MPL

Provenance

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