Article
Modeling myeloproliferative neoplasms: From mutations to mouse models and back again.
Blood reviews - 1 May 2017
Morotti Alessandro, Rocca Stefania, Carrà Giovanna, Saglio Giuseppe, Brancaccio Mara
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are defined according to the 2008 World Health Organization (WHO) classification and the recent 2016 revision. Over the years, several genetic lesions have been associated with the development of MPNs, with important consequences for identifying unique biomarkers associated with specific neoplasms and for developing targeted therapies. Defining the genotype-phenotype...
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