Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML

2 Jun 2017

Abstract excerpt

cells as harboring the disease-initiating compartment in vivo. Successful engraftments of JMML primary samples were also achieved in all NSGS recipients (n = 4 patients, n = 12 mice). Engraftment of CMML and JMML resulted in overt phenotypic abnormalities and lethality in recipients, which facilitated evaluation of the JAK2/FLT3 inhibitor pacritinib in vivo. These data reveal that NSGS mice support the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Immunodeficiency and Autoimmune Disorders
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28576879
DOI: 10.1182/blood-2017-01-763219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMMLPMID 28576879Read ↗

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical StudiesSemantic proximity Read ↗

A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative NeoplasmsSemantic proximity Read ↗

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studiesSemantic proximity Read ↗

A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms.Semantic proximity Read ↗

Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm-blast phase.Semantic proximity Read ↗

Mouse Models of CMML.Semantic proximity Read ↗

Humanized mouse models in MDSSemantic proximity Read ↗

Phenotypic characterization of disease-initiating stem cells in JAK2- or CALR-mutated myeloproliferative neoplasms.Semantic proximity Read ↗

Modeling myeloproliferative neoplasms: From mutations to mouse models and back again.Semantic proximity Read ↗

Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.Semantic proximity Read ↗

Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment.Semantic proximity Read ↗

Altered erythropoiesis via JAK2 and ASXL1 mutations in myeloproliferative neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.