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Murine Modeling of Myeloproliferative Neoplasms.

Hematology/oncology clinics of North America - 1 Apr 2021

Chen Karie, Shih Alan H

Abstract excerpt

Myeloproliferative neoplasms, such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are bone marrow disorders that result in the overproduction of mature clonal myeloid elements. Identification of recurrent genetic mutations has been described and aid in diagnosis and prognostic determination. Mouse models of these mutations have confirmed the biologic significance of these mutations in...

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PMID: 33641867
DOI: 10.1016/j.hoc.2020.11.007

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