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Article

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

21 Jan 2019

Abstract excerpt

Comprehensive preclinical studies of Myelodysplastic Syndromes (MDS) have been elusive due to limited ability of MDS stem cells to engraft current immunodeficient murine hosts. Here we report a MDS patient-derived xenotransplantation model in cytokine-humanized immunodeficient "MISTRG" mice that provides efficient and faithful disease representation across all MDS subtypes. MISTRG MDS patient-derived xenografts...

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PMID: 30664659
DOI: 10.1038/s41467-018-08166-x

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