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Article

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies

2018-02-14

Abstract excerpt

Comprehensive preclinical studies of Myelodysplastic Syndromes (MDS) have been elusive due to limited ability of MDS stem cells to engraft current immunodeficient murine hosts. We developed a novel MDS patient-derived xenotransplantation model in cytokine-humanized immunodeficient "MISTRG" mice that for the first time provides efficient and faithful disease representation across all MDS subtypes. MISTRG MDS patien...

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Literature Corpus work
3e127b19-6bfd-5c7a-a30a-372102cde4ef
DOI
10.1101/265082
Open publication

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A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical StudiesDOI 10.1101/265082
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