Article
A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms.
Cancer discovery - 1 Dec 2021
Celik Hamza, Krug Ethan, Zhang Christine R, Han Wentao, Issa Nancy, Koh Won Kyun, Bjeije Hassan, Kukhar Ostap, Allen Maggie, Li Tiandao, Fisher Daniel A C, Fowles Jared S, Wong Terrence N, Stubbs Matthew C, Koblish Holly K, Oh Stephen T, Challen Grant A
Abstract excerpt
Myeloproliferative neoplasms (MPN) are chronic blood diseases with significant morbidity and mortality. Although sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a significant proportion of patients progressing to rapidly fatal secondary acute myeloid leukemia (sAML). Therapeutic discovery has been hampered by the inability of genetically...
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