[Experimental model systems of primary myelofibrosis].

Abstract excerpt

Myeloproliferative neoplasms are a group of clonal proliferative diseases originating from hematopoietic stem cells, with a risk of transformation to acute myeloid leukemia. Primary myelofibrosis (PMF) is a subtype of myeloproliferative neoplasms. Mutations in Janus kinase 2 (JAK2), calreticulin (CALR), and thrombopoietin receptor (MPL) genes are the main pathogenic factors in PMF patients. Current therapeutic...

Topics

• Primary Myelofibrosis
• Humans
• Animals
• Janus Kinase 2
• Receptors, Thrombopoietin
• Calreticulin
• Disease Models, Animal