Article

A Cost-Effective and Easy to Assemble 3D Human Microchannel-Blood-Brain Barrier Model and Its Application in Tumor Metastasis

2025-01-07

Abstract excerpt

By utilizing PDMS, collagen hydrogel and a cell line for human cerebral microvascular endothelial cells, we generated a 3D microchannel-BBB model under physiological flows. This 3D BBB has a circular shaped cross-section and a diameter of ~100m, which can properly mimic the cerebral microvessel responsible for material exchange between the circulating blood and brain tissue. The permeability of the 3D microchannel...

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Literature Corpus work: 8589766b-84fb-55b5-82a9-8387a1a57e76
DOI: 10.20944/preprints202501.0490.v1

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