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PASTA 2.0: an improved server for protein aggregation prediction

21 May 2014

Abstract excerpt

The formation of amyloid aggregates upon protein misfolding is related to several devastating degenerative diseases. The propensities of different protein sequences to aggregate into amyloids, how they are enhanced by pathogenic mutations, the presence of aggregation hot spots stabilizing pathological interactions, the establishing of cross-amyloid interactions between co-aggregating proteins, all rely at the...

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PMID: 24848016
DOI: 10.1093/nar/gku399

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