Article

Dual impact of PTEN mutation on CSF dynamics and cortical networks via the dysregulation of neural precursors and their interneuron descendants

2023-03-19

Abstract excerpt

<h4>SUMMARY</h4> Expansion of the cerebrospinal fluid (CSF)-filled cerebral ventricles (ventriculomegaly) is the quintessential feature of congenital hydrocephalus (CH) but also seen in autism spectrum disorder (ASD) and several neuropsychiatric diseases. PTEN is frequently mutated in ASD; here, we show PTEN is a bona fide risk gene for the development of ventriculomegaly, including neurosurgically-treated CH....

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Literature Corpus work: b4653886-18ad-58ce-b8ce-5287bdae55c0
DOI: 10.1101/2023.03.18.533275

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