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Translatome analysis of Tuberous Sclerosis Complex-1 patient-derived neural progenitor cells reveal rapamycin-dependent and independent alterations

2023-03-27

Abstract excerpt

<title>Abstract</title> Tuberous sclerosis complex (TSC) is an inherited neurocutaneous disorder caused by mutations in <italic>TSC1 </italic>or <italic>TSC2 </italic>genes, with patients often exhibiting neurodevelopmental (ND) manifestations termed TSC-associated neuropsychiatric disorders (TAND) including autism spectrum disorder (ASD). The hamartin-tuberin (TSC1-TSC2) protein complex inactivates mechanisti...

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Literature Corpus work: b9837e14-caad-5082-be54-ca19f6c2170d
DOI: 10.21203/rs.3.rs-2702044/v1

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