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Transcriptomic Signatures of Mitochondrial Dysfunction in Autism: Integrated mRNA and microRNA Profiling

2025-07-23

Abstract excerpt

This study explores how mRNA and microRNA (miRNA) expression profiles distinguish subtypes of autism spectrum disorder (ASD) defined by mitochondrial function. Using lymphoblastoid cell lines (LCLs) from boys with ASD are classified into two groups: those with abnormal (AD-A) and normal (AD-N) mitochondrial function. Prior work established that about a third of ASD-derived LCLs show excessive mitochondrial respira...

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Literature Corpus work
b463eb2d-eeb5-5ee4-976c-8f5bb48c450c
DOI
10.20944/preprints202507.1905.v1
Open publication

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