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Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachment

2025-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Diabetic kidney disease involves hyperglycemia, inflammation, and epithelial cell dysfunction, but the relationship between these factors is not well understood. We demonstrate that human kidney organoids treated with elevated glucose exhibit a phenotype of epithelial detachment driven by tissue-intrinsic upregulation of proinflammatory cytokines, which can be targeted therapeutically. High gluc...

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Identifiers and source

Literature Corpus work
a125fa05-a37e-5555-9411-1f0c69f63859
DOI
10.1101/2025.09.05.669416
Open publication

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Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachmentDOI 10.1101/2025.09.05.669416
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