Article

A diabetic <i>milieu</i> increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patients

2021-08-13

Abstract excerpt

<h4>Summary</h4> SARS-CoV-2 infections lead to a high risk of hospitalization and mortality in diabetic patients. Why diabetic individuals are more prone to develop severe COVID-19 remains unclear. Here, we established a novel human kidney organoid model that mimics early hallmarks of diabetic nephropathy. High oscillatory glucose exposure resulted in metabolic changes, expansion of extracellular membrane compone...

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Literature Corpus work: b2ee98f4-bdc6-510b-bd46-8ce7ef49ba09
DOI: 10.1101/2021.08.13.456228

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