Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

12 May 2022

Abstract excerpt

It is not well understood why diabetic individuals are more prone to develop severe COVID-19. To this, we here established a human kidney organoid model promoting early hallmarks of diabetic kidney disease development. Upon SARS-CoV-2 infection, diabetic-like kidney organoids exhibited higher viral loads compared with their control counterparts. Genetic deletion of the angiotensin-converting enzyme 2 (ACE2) in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to Diabetes and associated disorders
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35561674
DOI: 10.1016/j.cmet.2022.04.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cellsPMID 35561674Read ↗

A diabetic <i>milieu</i> increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patientsSemantic proximity Read ↗

Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney diseaseSemantic proximity Read ↗

Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney DiseaseSemantic proximity Read ↗

Perspectives on systems biology applications in diabetic kidney disease.Semantic proximity Read ↗

Role of nuclear receptors, lipid metabolism, and mitochondrial function in the pathogenesis of diabetic kidney diseaseSemantic proximity Read ↗

Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning.Semantic proximity Read ↗

TFAM and Mitochondrial Protection in Diabetic Kidney DiseaseSemantic proximity Read ↗

Multiomics Analyses Identify AKR1A1 as a Biomarker for Diabetic Kidney DiseaseSemantic proximity Read ↗

Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachmentSemantic proximity Read ↗

Disruption of Immune Responses By Type I Diabetes Exacerbates SARS-CoV-2 Mediated Lung InjurySemantic proximity Read ↗

Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapiesSemantic proximity Read ↗

Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.