Back to search

Article

Multi-omic Characterization of Human Tubular Epithelial Cell Response to Serum

2021-01-29

Abstract excerpt

Proteinuria, the spillage of serum proteins into the urine, is a feature of glomerulonephritides, podocyte disorders and diabetic nephropathy. However, the response of tubular epithelial cells to serum protein exposure has not been systematically characterized. Using transcriptomic profiling we studied serum-induced changes in primary human tubular epithelial cells cultured in 3D microphysiological devices. Serum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
dd20de2b-9838-5972-a754-c6f351956977
DOI
10.1101/2021.01.29.428186
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Multi-omic Characterization of Human Tubular Epithelial Cell Response to SerumDOI 10.1101/2021.01.29.428186
An integrated organoid omics map extends modeling potential of kidney diseaseSemantic proximity
An integrated organoid omics map extends modeling potential of kidney diseaseSemantic proximity
Transcriptomic responses of the human kidney to acute injury at single cell resolutionSemantic proximity
Plasma proteomics of acute tubular injurySemantic proximity
Urinary single-cell sequencing captures intrarenal injury and repair processes in human acute kidney injurySemantic proximity
Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosisSemantic proximity
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progressionSemantic proximity
Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratificationSemantic proximity
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injurySemantic proximity
Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progressionSemantic proximity
Single-Cell RNA Sequencing of Urinary Cells Reveals Distinct Cellular Diversity in COVID-19–Associated AKISemantic proximity
Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human KidneySemantic proximity
Select a neighboring publication to make it the new centre.