Article
Pro-inflammatory/Th1 gene expression shift in high glucose stimulated mesangial cells and tubular epithelial cells.
Biochemical and biophysical research communications - 17 Jan 2014
Iwata Yasunori, Furuichi Kengo, Hashimoto Shinichi, Yokota Kiyonobu, Yasuda Haruka, Sakai Norihiko, Kitajima Shinji, Toyama Tadashi, Shinozaki Yasuyuki, Sagara Akihiro, Matsushima Kouji, Kaneko Shuichi, Wada Takashi
Abstract excerpt
Diabetic nephropathy (DN) is a major cause of end stage kidney disease and a strong risk factor for cardiovascular diseases. Growing data show chronic inflammation plays an important role for the progression of DN. As for the immune cells, anti-inflammatory leukocytes as well as pro-inflammatory leukocytes play an important role in DN. In addition to leukocytes, renal resident cells contribute to the inflammatory...
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