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Article

Multimodal characterization of age-dependent neurovascular phenotypes in Notch3R170C CADASIL mice by ultra-high-field MRI and histological analyses.

Brain research bulletin - 1 Oct 2026

Yang Junting, Tian Shan, Li Yuna, Qiao Yuan, Cong Chaohua, Zhang Lin, Su Jingjing, Wu Weibin

Abstract excerpt

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease caused by mutations in NOTCH3 and characterized by progressive neurovascular alterations. Although magnetic resonance imaging (MRI) can detect vascular and white matter abnormalities in CADASIL, the relationship between imaging findings and underlying cellular and molecular...

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Source

Identifiers

PMID: 42462891
DOI: 10.1016/j.brainresbull.2026.112051

Genes

NOTCH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Multimodal characterization of age-dependent neurovascular phenotypes in Notch3R170C CADASIL mice by ultra-high-field MRI and histological analyses.PMID 42462891Read ↗

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Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.Semantic proximity Read ↗

NOTCH3 R545C mutation drives vascular-neuronal dysfunction and cognitive impairment in CADASIL pathogenesis.Semantic proximity Read ↗

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Family Members With a Pathogenic NOTCH3 Variant Can Have a Normal Brain Magnetic Resonance Imaging and Skin Biopsy Beyond Age 50 Years.Semantic proximity Read ↗

NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL.Semantic proximity Read ↗

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Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL.Semantic proximity Read ↗

The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation.Semantic proximity Read ↗

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