Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies.

doi:10.1038/s41380-025-03357-7

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Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies.

Molecular psychiatry - 1 Apr 2026

Koch Elise, Puusepp Tuuli, Einarsson Guðmundur, Mitchell Brittany L, Harder Arvid, Lin Yuhao, García-Marín Luis M, Krebs Kristi, Shadrin Alexey A, Xiong Ying, Frei Oleksandr, Lu Yi, Hägg Sara, Rentería Miguel E, Medland Sarah E, Wray Naomi R, Martin Nicholas G, Hübel Christopher, Breen Gerome, Thorgeirsson Thorgeir, Stefánsson Hreinn, Stefánsson Kári, Lehto Kelli, Milani Lili, Andreassen Ole A, O'Connell Kevin S

Abstract excerpt

Antidepressants exhibit a considerable variation in efficacy, and increasing evidence suggests that individual genetics contribute to antidepressant treatment response. Here, we combined data on antidepressant non-response measured using rating scales for depressive symptoms, questionnaires of treatment effect, and data from electronic health records, to increase statistical power to detect genomic loci...

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PMID: 41261141
DOI: 10.1038/s41380-025-03357-7

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