Article

Astrocytic FABP5 drives non-cell-autonomous oligodendrocyte injury in multiple system atrophy by promoting TNF signaling and ferroptotic stress

2025-11-10

Abstract excerpt

Multiple system atrophy (MSA) is a fatal α-synucleinopathy characterized by progressive parkinsonism, cerebellar and autonomic dysfunction. Currently, the mechanisms driving cerebellar white matter neuroinflammation and degeneration in MSA are poorly understood. Here, we identified fatty acid-binding protein 5 (FABP5) as a key factor regulating cerebellar inflammation in MSA pathogenesis in a detailed study of hum...

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Literature Corpus work: a112690a-b215-5981-8f30-7b884be4a0db
DOI: 10.1101/2025.11.08.687320

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