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Article

Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation

21 Apr 2023

Abstract excerpt

Multiple system atrophy (MSA) is a neurodegenerative disease characterized by the accumulation of misfolded α-synuclein (αSyn) and myelin disruption. However, the mechanism underlying αSyn accumulation in MSA brains remains unclear. Here, we aimed to identify epsin-2 as a potential regulator of αSyn propagation in MSA brains. In the MSA mouse model, PLP-hαSyn mice, and FABP7/αSyn hetero-aggregate-injected mice,...

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PMID: 37082980
DOI: 10.1093/brain/awad137

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