Article

A Cyclisation and Docking Protocol for Cyclic Peptide-Protein Modelling using HADDOCK2.4

2022-01-23

Abstract excerpt

An emerging class of therapeutic molecules are cyclic peptides with over 40 cyclic peptide drugs currently in clinical use. Their mode of action is, however, not fully understood, impeding rational drug design. Computational techniques could positively impact their design but modeling them and their interactions remains challenging due to their cyclic nature and their flexibility. This study presents a step-by-ste...

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Literature Corpus work: a0faf23f-5057-5974-b504-f262f79b8ea8
DOI: 10.1101/2022.01.21.477251

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