Article

Target-based <i>de novo</i> design of cyclic peptide binders

2025-01-19

Abstract excerpt

Cyclic peptides have become a new focus in drug discovery due to their ability to bind challenging targets, including “undruggable” protein-protein interactions, with low toxicity. Despite their potential, general methods for de novo design of cyclic peptide ligands based on target protein structures remain limited. Here, we developed CYC_BUILDER, a reinforcement learning based fragment growing method for efficie...

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Literature Corpus work: 3ce04266-4154-55a0-b31e-cce1ae0fe233
DOI: 10.1101/2025.01.18.633746

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