A minimalistic cyclic ice-binding peptide from phage display.

Abstract excerpt

Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Rather than relying on the (limited) existing structure-property relationships that have been established for IBPs, here we report the use of phage display for the identification of short peptide mimics of IBPs. To this end, an ice-affinity selection protocol is developed, which enables the...

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• Amino Acids
• Binding Sites
• Crystallization
• Hydrophobic and Hydrophilic Interactions
• Molecular Dynamics Simulation