Article

Structure-Based Design of a Cyclic Peptide Inhibitor of the SARS-CoV-2 Main Protease

2020-08-03

Abstract excerpt

<h4>ABSTRACT</h4> This paper presents the design and study of a first-in-class cyclic peptide inhibitor against the SARS-CoV-2 main protease (M pro ). The cyclic peptide inhibitor is designed to mimic the conformation of a substrate at a C -terminal autolytic cleavage site of M pro . Synthesis and evaluation of a first-generation cyclic peptide inhibitor reveals that the inhibitor is active against M pro in v...

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Literature Corpus work: ec6b7ee9-0503-57b0-bf29-4fdc411994a1
DOI: 10.1101/2020.08.03.234872

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