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DHODH and cancer: promising prospects to be explored

10 May 2021

Abstract excerpt

Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is originally a target for the treatment of the non-neoplastic diseases involving in rheumatoid arthritis and multiple sclerosis, and is re-emerging as a validated therapeutic target for cancer therapy. In this review, we mainly unravel the biological...

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PMID: 33971967
DOI: 10.1186/s40170-021-00250-z

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