Article

N4-hydroxycytidine and inhibitors of dihydroorotate dehydrogenase synergistically suppress SARS-CoV-2 replication

2021-06-28

Abstract excerpt

<h4>ABSTRACT</h4> Effective therapeutics to inhibit the replication of SARS-CoV-2 in infected individuals are still under development. The nucleoside analogue N4-hydroxycytidine (NHC), also known as EIDD-1931, interferes with SARS-CoV-2 replication in cell culture. It is the active metabolite of the prodrug Molnupiravir (MK-4482), which is currently being evaluated for the treatment of COVID-19 in advanced clinic...

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Literature Corpus work: 77c89f10-c9d7-56e9-b544-cc46abe7d080
DOI: 10.1101/2021.06.28.450163

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