Article

N4-Hydroxycytidine and Inhibitors of Dihydroorotate Dehydrogenase Synergistically Suppress SARS-CoV-2 Replication

2022-01-25

Abstract excerpt

SARS-CoV-2 incorporates the nucleoside analogue N4-hydroxycytidine (NHC) into its RNA through the RNA-dependent RNA polymerase (RdRp). NHC is the active metabolite of the prodrug Molnupiravir (MK-4482), which has recently been approved in the United Kingdom (UK) for the treatment of COVID-19. Likewise, inhibitors of dihydroorotate dehydrogenase (DHODH), by reducing the cellular synthesis of pyrimidines, also reduc...

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Literature Corpus work: d890192f-f5af-54f1-a96c-3b0e36db7880
DOI: 10.2139/ssrn.4017904

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