Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses

28 Apr 2022

Abstract excerpt

New strategies to rapidly develop broad-spectrum antiviral therapies are urgently required for emerging and re-emerging viruses. Host-targeting antivirals (HTAs) that target the universal host factors necessary for viral replication are the most promising approach, with broad-spectrum, foresighted function, and low resistance. We and others recently identified that host dihydroorotate dehydrogenase (DHODH) is one...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent and Pediatric Healthcare
Share to Biochemical and Molecular Research
Share to Neonatal Health and Biochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35632670
DOI: 10.3390/v14050928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging VirusesPMID 35632670Read ↗

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2Semantic proximity Read ↗

The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human CoronavirusesSemantic proximity Read ↗

Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2Semantic proximity Read ↗

The new generation hDHODH inhibitor MEDS433 hinders the <i>in vitro</i> replication of SARS-CoV-2Semantic proximity Read ↗

Brequinar and Dipyridamole in Combination Exhibits Synergistic Antiviral Activity Against SARS-CoV-2 <i>in vitro</i> : Rationale for a host-acting antiviral treatment strategy for COVID-19Semantic proximity Read ↗

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral InhibitorsSemantic proximity Read ↗

Medicinal chemistry strategies toward host targeting antiviral agentsSemantic proximity Read ↗

Host directed therapies: COVID-19 and beyondSemantic proximity Read ↗

A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antiviralsSemantic proximity Read ↗

Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targetsSemantic proximity Read ↗

Hepatitis Delta Virus: Replication Strategy and Upcoming Therapeutic Options for a Neglected Human PathogenSemantic proximity Read ↗

DHODH and cancer: promising prospects to be exploredSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.