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Article

Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

4 Mar 2019

Abstract excerpt

Objective Hepatitis D virus (HDV) is a circular RNA virus coinfecting hepatocytes with hepatitis B virus. Chronic hepatitis D results in severe liver disease and an increased risk of liver cancer. Efficient therapeutic approaches against HDV are absent. Design Here, we combined an RNAi loss-of-function and small molecule screen to uncover host-dependency factors for HDV infection. Results Functional screening...

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PMID: 30833451
DOI: 10.1136/gutjnl-2018-317065

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