Article

Microbiome Integrity Protects Against Glial-Mediated Tau and Amyloid Pathology Through Circadian and Autophagy Homeostasis

2026-05-22

Abstract excerpt

Alzheimer disease referred as AD is characterized not only by tau and amyloid beta aggregation but also by systemic disruptions in circadian rhythms, metabolism, and gut-brain communication that exacerbate neuroinflammation and neurodegeneration. While glial cells play central roles in inflammatory signaling and proteostasis, the contribution of the gut microbiome to glia-driven AD pathology remains poorly underst...

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Literature Corpus work: 1b4629cb-eb3d-5457-a04c-4b142ffc7efc
DOI: 10.64898/2026.05.20.726549

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