Article

Delayed growth of SK-ES-1 Ewing sarcoma tumors associated with reduced expression and activity of Trk receptors, PI3K, and IGF1R

2025-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Ewing sarcoma (ES) is an aggressive childhood tumor. We have previously shown that tropomyosin receptor kinase (Trk) neurotrophin receptors regulate viability, and the pan-Trk and kinase inhibitor K252a restores sensitivity to chemotherapy, in ES cells. Here, we show that administration of K252a in mice delays ES tumor growth and reduces expression and activity of multiple targets. BALB/c nu/nu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0ce1759-ed3b-5b0a-a14f-d792f8eb4e75
DOI: 10.1101/2025.10.23.684233

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Delayed growth of SK-ES-1 Ewing sarcoma tumors associated with reduced expression and activity of Trk receptors, PI3K, and IGF1RDOI 10.1101/2025.10.23.684233Read

Trk Receptor Expression and Inhibition in NeuroblastomasSemantic proximity Read

RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma.Semantic proximity Read

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTsSemantic proximity Read

ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse modelsSemantic proximity Read

tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafishSemantic proximity Read

ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse modelsSemantic proximity Read

Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcomaSemantic proximity Read

Oncogenic role of a developmentally regulated <i>NTRK2</i> splice variantSemantic proximity Read

Inhibiting TRK Proteins in Clinical Cancer TherapySemantic proximity Read

Establishment and characterization of a patient-derived metastatic extraskeletal Ewing sarcoma cell line ES-ZSS-1.Semantic proximity Read

Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children’s Oncology Group (COG) New Agents for Ewing Sarcoma Task ForceSemantic proximity Read

Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput ScreeningSemantic proximity Read