Article

Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children’s Oncology Group (COG) New Agents for Ewing Sarcoma Task Force

2019-04-15

Abstract excerpt

Ewing sarcoma is a small round blue cell malignancy arising from bone or soft tissue and most commonly affects adolescents and young adults. Metastatic and relapsed Ewing sarcoma have poor outcomes and recurrences remain common. Owing to the poor outcomes associated with advanced disease and the need for a clear research strategy, the Children’s Oncology Group Bone Tumor Committee formed the New Agents for Ewing S...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eb1ef113-8ef5-5801-af23-820b58844b44
DOI: 10.12688/f1000research.18139.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children’s Oncology Group (COG) New Agents for Ewing Sarcoma Task ForceDOI 10.12688/f1000research.18139.1Read

Recent advances in targeted therapy for Ewing sarcomaSemantic proximity Read

Ewing Sarcoma: Biology-Based Therapeutic PerspectivesSemantic proximity Read

Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape.Semantic proximity Read

Signaling pathways and targeted therapies in Ewing sarcomaSemantic proximity Read

A novel combination of CDK4/6 and PI3K inhibitors exhibits highly synergistic activity and translational potential in Ewing sarcomaSemantic proximity Read

Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway SignalingSemantic proximity Read

Pediatric Malignant Bone Tumors: A Review and Update on Current Challenges, and Emerging Drug Targets.Semantic proximity Read

Ewing and Ewing-like-sarcoma tumoroid biobank reveals distinct drug sensitivities: translocation makes the differenceSemantic proximity Read

Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapiesSemantic proximity Read

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcomaSemantic proximity Read

Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA ExpressionSemantic proximity Read

Ewing sarcoma: a tough road to clinically relevant biomarkers.Semantic proximity Read