Article

ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models

2024-03-13

Abstract excerpt

Pediatric-type high-grade gliomas frequently harbor gene fusions involving receptor tyrosine kinase genes, including neurotrophic tyrosine kinase receptor (NTRK) fusions. Clinically, these tumors show high initial response rates to tyrosine kinase inhibition but ultimately recur due to the accumulation of additional resistance-conferring mutations. Here, we developed a series of genetically engineered mouse models...

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Literature Corpus work: d311e779-e885-563f-8950-834a0c67c0d8
DOI: 10.1101/2024.03.13.584849

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