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Article

Inhibiting TRK Proteins in Clinical Cancer Therapy

4 Apr 2018

Abstract excerpt

Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase (TRK) family of tyrosine receptor kinases is emerging as an important target for cancer therapeutics. The TRK family contains three members, TRKA, TRKB, and TRKC, and these proteins are encoded by the genes NTRK1, NTRK2, and NTRK3,...

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PMID: 29617282
DOI: 10.3390/cancers10040105

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