Article

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

2023-06-26

Abstract excerpt

<title>Abstract</title> <p>Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in neurofibromatosis type 1 (NF1). Although NF1-related MPNSTs derive from neural crest cell origin, they also exhibit intratumoral heterogeneity. <italic>TP53</italic> mutations are associated with significantly decreased survival in MPNSTs, however the mechanisms und...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ae5b82c-7adf-5f2b-ab08-ee2addec73c3
DOI: 10.21203/rs.3.rs-3030556/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTsDOI 10.21203/rs.3.rs-3030556/v1Read

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTsSemantic proximity Read

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTsSemantic proximity Read

Genomic MET amplification occurs early in NF1-related malignant peripheral nerve sheath tumor (MPNST) progression and is a potent therapeutic targetSemantic proximity Read

Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath TumorsSemantic proximity Read

YAP signaling promotes resistance to MEK and AKT inhibition in <i>NF1</i> -related MPNSTsSemantic proximity Read

Trp53 Haploinsufficiency Modifies EGFR-Driven Peripheral Nerve Sheath TumorigenesisSemantic proximity Read

Functional interactions between neurofibromatosis tumor suppressors drive Schwann cell tumor de-differentiation and treatment resistanceSemantic proximity Read

Oncogenic RAS-MET signal interactions are modulated by P53 status in NF1-related MPNSTsSemantic proximity Read

PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath TumorsSemantic proximity Read

Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistanceSemantic proximity Read

A genetic mouse model with postnatal <i>Nf1</i> and <i>p53</i> loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumorSemantic proximity Read

Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosisSemantic proximity Read