Article

Merlin Tumor Suppressor Function is Regulated by PIP <sub>2</sub> -Mediated Dimerization

2021-11-12

Abstract excerpt

Neurofibromatosis Type 2 is an inherited disease characterized by Schwann cell tumors of cranial and peripheral nerves. The NF2 gene encodes Merlin, a member of the ERM family consisting of an N-terminal FERM domain, a central α-helical region and a C-terminal domain that binds to the FERM domain. Changes in the intermolecular FERM-CTD interaction allow Merlin to transition between an open, FERM accessible confor...

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Literature Corpus work: a0c00b39-86f8-51c1-80ee-38719617a978
DOI: 10.1101/2021.11.11.468247

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