Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin

15 Mar 1999

Abstract excerpt

Ezrin, radixin and moesin (ERM) are homologous proteins, which are linkers between plasma membrane components and the actin-containing cytoskeleton. The ERM protein family members associate with each other in a homotypic and heterotypic manner. The neurofibromatosis 2 (NF2) tumor suppressor protein merlin (schwannomin) is structurally related to ERM members. Merlin is involved in tumorigenesis of NF2-associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axon Guidance and Neuronal Signaling
Share to Hippo pathway signaling and YAP/TAZ
Share to Neurofibromatosis and Schwannoma Cases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10036239
DOI: 10.1242/jcs.112.6.895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrinPMID 10036239Read ↗

Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlinSemantic proximity Read ↗

Merlin differentially associates with the microtubule and actin cytoskeletonSemantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity.Semantic proximity Read ↗

Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cellsSemantic proximity Read ↗

The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeletonSemantic proximity Read ↗

Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins.Semantic proximity Read ↗

The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene productSemantic proximity Read ↗

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading.Semantic proximity Read ↗

[Neurofibromatosis type 2 (NF2)].Semantic proximity Read ↗

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular LocalizationSemantic proximity Read ↗

Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.