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Article

The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product

21 Feb 2002

Abstract excerpt

Neurofibromatosis type 2 is an autosomal dominant disorder characterized by central nervous system tumors. The cause of the disease has been traced to mutations in the gene coding for a protein that is alternately called merlin or schwannomin and is a member of the ERM family (ezrin, radixin and moesin). The ERM proteins link the cytoskeleton to the cell membrane either directly through integral membrane proteins...

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PMID: 11856822
DOI: 10.1107/s0907444901021175

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The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene productPMID 11856822Read ↗

Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.Semantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cellsSemantic proximity Read ↗

A glimpse of the ERM proteinsSemantic proximity Read ↗

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular LocalizationSemantic proximity Read ↗

Structure-function relationships in the ezrin family and the effect of tumor-associated point mutations in neurofibromatosis 2 protein.Semantic proximity Read ↗

Conformational flexibility determines the Nf2/merlin tumor suppressor functionsSemantic proximity Read ↗

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Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrinSemantic proximity Read ↗

NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.Semantic proximity Read ↗

Merlin differentially associates with the microtubule and actin cytoskeletonSemantic proximity Read ↗

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