Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells

12 Nov 2009

Abstract excerpt

Merlin is the product of the Nf2 tumor-suppressor gene, and inactivation of Nf2 leads to the development of neural tumors such as schwannomas and meningiomas in humans and mice. Merlin is a member of the ERM (ezrin, radixin and moesin) family of proteins that function as organizers of the actin cytoskeleton. Merlin structure is thought to be similar to that of the ERM proteins, and is held in a closed clamp...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Mechanics and Interactions
Share to Hippo pathway signaling and YAP/TAZ
Share to Neurofibromatosis and Schwannoma Cases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19910496
DOI: 10.1242/jcs.045914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cellsPMID 19910496Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

<i>NF2</i>: The wizardry of merlinSemantic proximity Read ↗

NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.Semantic proximity Read ↗

Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.Semantic proximity Read ↗

Merlin differentially associates with the microtubule and actin cytoskeletonSemantic proximity Read ↗

Shedding light on Merlin's wizardry.Semantic proximity Read ↗

The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeletonSemantic proximity Read ↗

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular LocalizationSemantic proximity Read ↗

p21-activated Kinase Links Rac/Cdc42 Signaling to MerlinSemantic proximity Read ↗

The Role of Merlin/NF2 Loss in Meningioma BiologySemantic proximity Read ↗

Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.