NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.

doi:10.3390/ijms19040988

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Article

NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.

International journal of molecular sciences - 26 Mar 2018

Sato Tatsuhiro, Sekido Yoshitaka

Abstract excerpt

The neurofibromatosis type 2 (NF2) gene encodes merlin, a tumor suppressor protein frequently inactivated in schwannoma, meningioma, and malignant mesothelioma (MM). The sequence of merlin is similar to that of ezrin/radixin/moesin (ERM) proteins which crosslink actin with the plasma membrane, suggesting that merlin plays a role in transducing extracellular signals to the actin cytoskeleton. Merlin adopts a...

Topics

Actins
Antineoplastic Agents
Gene Expression Regulation, Neoplastic
Genetic Variation
Hippo Signaling Pathway
Humans
Lung Neoplasms
Mesothelioma
Mesothelioma, Malignant
Neurofibromin 2
Protein Serine-Threonine Kinases
Signal Transduction
TOR Serine-Threonine Kinases

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Identifiers

PMID: 29587439
DOI: 10.3390/ijms19040988
PMCID: PMC5979333

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