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Article

NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.

International journal of molecular sciences - 26 Mar 2018

Sato Tatsuhiro, Sekido Yoshitaka

Abstract excerpt

The neurofibromatosis type 2 (NF2) gene encodes merlin, a tumor suppressor protein frequently inactivated in schwannoma, meningioma, and malignant mesothelioma (MM). The sequence of merlin is similar to that of ezrin/radixin/moesin (ERM) proteins which crosslink actin with the plasma membrane, suggesting that merlin plays a role in transducing extracellular signals to the actin cytoskeleton. Merlin adopts a...

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Identifiers

PMID: 29587439
DOI: 10.3390/ijms19040988
PMCID: PMC5979333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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