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Article

The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin.

Biochemical and biophysical research communications - 14 May 2021

Zhang Fayou, Liu Beibei, Gao Yaqi, Long Jiafu, Zhou Hao

Abstract excerpt

NF2/Merlin is an upstream regulator of hippo pathway, and it has two states: an auto-inhibited "closed" state and an active "open" form. Previous studies showed that Drosophila Merlin adopts a more closed conformation. However, the molecular mechanism of conformational regulation remains poorly understood. Here, we first confirmed the strong interaction between FERM and the C-terminal domain (CTD) of Merlin, and...

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PMID: 33765559
DOI: 10.1016/j.bbrc.2021.03.065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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