Article

Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes

2024-12-05

Abstract excerpt

<h4>Background</h4> Small intestinal neuroendocrine tumours (SI-NETs) are the most common malignancy of the small intestine and around 50% of patients present in clinic with multifocal disease. Recent investigations into the genomic architecture of multifocal SI-NETs have found evidence that these synchronous primary tumours evolve independently of each other. They also have extremely low mutational burden and fe...

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Literature Corpus work: a0bc2e42-0fbc-5f28-959e-dff9b9b34ed3
DOI: 10.1101/2024.12.02.626017

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