Article

A single-cell transcriptomic comparison between small intestinal neuroendocrine tumors and their progenitor

2025-02-15

Abstract excerpt

Several studies have attempted to find the initiating drivers of small intestinal neuroendocrine tumors (SI-NET) development and the molecular mechanisms driving progression and metastatic spread. For gene expression studies using bulk microarrays and RNA sequencing, researchers commonly use normal intestinal mucosa as a control. The intestine is made up of several different cell types, and using bulk RNA-seq may...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a6ff1b4-56a1-51b7-a6f1-aea48d313b86
DOI: 10.1101/2025.02.10.637596

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single-cell transcriptomic comparison between small intestinal neuroendocrine tumors and their progenitorDOI 10.1101/2025.02.10.637596Read

Comprehensive molecular portrait reveals genetic diversity and distinct molecular subtypes of small intestinal neuroendocrine tumorsSemantic proximity Read

Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor.Semantic proximity Read

Integrated genomic analysis of small intestinal neuroendocrine tumors provides further insights into molecular subgroups and identifies putative driver genesSemantic proximity Read

The genomic landscape of small intestine neuroendocrine tumors.Semantic proximity Read

Multiomic sequencing of paired primary and metastatic small bowel carcinoidsSemantic proximity Read

Gene network-based analysis identifies two potential subtypes of small intestinal neuroendocrine tumorsSemantic proximity Read

Genetics and epigenetics in small intestinal neuroendocrine tumours.Semantic proximity Read

Small intestinal neuroendocrine tumors lack early genomic drivers, acquire DNA repair defects and harbor hallmarks of low REST expressionSemantic proximity Read

Intestinal cellular heterogeneity and disease development revealed by single-cell technologySemantic proximity Read

Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma RemainsSemantic proximity Read

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.Semantic proximity Read

Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasmsSemantic proximity Read