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Article

Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine.

Nature communications - 4 Nov 2021

Elias Erik, Ardalan Arman, Lindberg Markus, Reinsbach Susanne E, Muth Andreas, Nilsson Ola, Arvidsson Yvonne, Larsson Erik

Abstract excerpt

Small intestine neuroendocrine tumor (SI-NET), the most common cancer of the small bowel, often displays a curious multifocal phenotype with several tumors clustered together in a limited intestinal segment. SI-NET also shows an unusual absence of driver mutations explaining tumor initiation and metastatic spread. The evolutionary trajectories that underlie multifocal SI-NET lesions could provide insight into the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34737276
DOI: 10.1038/s41467-021-26581-5
PMCID: PMC8568927

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