Article
Whole genome sequencing reveals the independent clonal origin of multifocal ileal neuroendocrine tumors.
Genome medicine - 3 Aug 2022
Mäkinen Netta, Zhou Meng, Zhang Zhouwei, Kasai Yosuke, Perez Elizabeth, Kim Grace E, Thirlwell Chrissie, Nakakura Eric, Meyerson Matthew
Abstract excerpt
BACKGROUND: Small intestinal neuroendocrine tumors (SI-NETs) are the most common neoplasms of the small bowel. The majority of tumors are located in the distal ileum with a high incidence of multiple synchronous primary tumors. Even though up to 50% of SI-NET patients are diagnosed with multifocal disease, the mechanisms underlying multiple synchronous lesions remain elusive. METHODS: We performed whole genome...
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