Article
The genomic landscape of small intestine neuroendocrine tumors.
The Journal of clinical investigation - 1 Jun 2013
Banck Michaela S, Kanwar Rahul, Kulkarni Amit A, Boora Ganesh K, Metge Franziska, Kipp Benjamin R, Zhang Lizhi, Thorland Erik C, Minn Kay T, Tentu Ramesh, Eckloff Bruce W, Wieben Eric D, Wu Yanhong, Cunningham Julie M, Nagorney David M, Gilbert Judith A, Ames Matthew M, Beutler Andreas S
Abstract excerpt
Small intestine neuroendocrine tumors (SI-NETs) are the most common malignancy of the small bowel. Several clinical trials target PI3K/Akt/mTOR signaling; however, it is unknown whether these or other genes are genetically altered in these tumors. To address the underlying genetics, we analyzed 48 SI-NETs by massively parallel exome sequencing. We detected an average of 0.1 somatic single nucleotide variants...
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