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Article

Genetic heterogeneity of primary lesion and metastasis in small intestine neuroendocrine tumors.

Scientific reports - 28 Feb 2018

Walter Dirk, Harter Patrick N, Battke Florian, Winkelmann Ria, Schneider Markus, Holzer Katharina, Koch Christine, Bojunga Jörg, Zeuzem Stefan, Hansmann Martin Leo, Peveling-Oberhag Jan, Waidmann Oliver

Abstract excerpt

Data on intratumoral heterogeneity of small intestine neuroendocrine tumors (SI-NETs) and related liver metastasis are limited. The aim of this study was to characterize genetic heterogeneity of 5 patients with SI-NETs. Therefore, formalin-fixed, paraffin-embedded tissue samples of primary and metastatic lesions as well as benign liver of five patients with synchronously metastasized, well differentiated SI-NETs...

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Identifiers

PMID: 29491456
DOI: 10.1038/s41598-018-22115-0
PMCID: PMC5830878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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